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KMID : 0364019960290070689
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Korean Journal of Thoracic and Cardiovascular Surgery
1996 Volume.29 No. 7 p.689 ~ p.699
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An Animal Study on Electrohydraulic Type Ventricular Assist Device
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백완기
심상석/진성훈/원용순/김원곤/노준량/박성근/민병구
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Abstract
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An animal experiment was designed for the evaluation of in vivo performance of the newly developed electrohydraulic type ventricular assist device and its influence on the left ventricular function during pulsatile left ventricular assist.
Eight adult sheep were incorporated into the study and data were collected from seven sheep. Total assist time ranged from 69 minutes to 7 days. The performance of the device was satisfactory both in asynchronous and synchronous mode within the
range of
given native haart rate. More than 4 liters of device output could be reached within the range of normal left atral pressure without development of negative pressure in the left atrium.
Moberate to severe degree of hemolysis was noted as evidenced by significant increase of plasma free hemoglobin level after 3 days of left ventricular support along with the presence of the small amount of thrombi around the floating disc type
polymer
valve apparatus reflecting that further study and refinement of the device need to be done in regard of biocompatibility and thromboresistance.
The hemodynamics showed increase in heart rate(p<0.05), cardiac output and left ventricular minute work(p<0.05) after placement of the device at the flow rate of 2.0~2.5L/min. The left atrial pressure left ventricular pressure and LV dP/dt were
decreased after the device placement(p<0.05). The endocardial viability ratio and oxygen contents of the mixed venous blood and coronary venous blood were all increased(p<0.05) after the device placement suggesting effective unloading of the left
ventricle was accomplished.
The myocardial perfusion was thought improved in synchronous counterpulsation as suggested by significant increase in endocardial viability ratio and coronary venous blood oxygen content in synchronous assist mode comparing with asynchronous
mode.
This data suggests synchronous counterpulsation might be advantageous for the recovery of the heart from an ischemic yet potentially reversible myocardial injury.
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